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KMID : 0378119760030010038
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Chungnam Medical Journal
1976 Volume.3 No. 1 p.38 ~ p.44
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Effect of Intraventricular Neostigmine on the Renal Function of Rabbit
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Abstract
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Effect of neostigmine administered intracerebroventricularly on the renal function.-of rabbits was investigated.
1) Intraventricular neostigmine induced decrease after initial increase of urine flow and changes of renal plasma flow, glomerular filtration and urinary sodium and potassium excretion in proportion to urine flow approximately, but did not influence to filtration fraction and reabsorption of sodium and potassium.
2) Correlation coefficient between changes of two parameters among urine volume, renal plasma flow, glomerular filtration and urinary sodium excretion was statistically significant.
3) Increasing changes of various parameters of renal function induced by intraventri-cular neostigmine were inhibited by intravenous atropine pretreatment and decreasing changes of the parameters partially inhibited by the blocking agent. Pretreatment withh intravenous regitine potentiated diuretic action and inhibited antidiuretic action. of intraventricular neostigmine.
From the above results, it is suggested that the effect of intraventricular neostigm-ine on the renal function of rabbit is due to renal hemodynamic changes by central parasympathetic and sympathetic activation.
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